pentobarbital will minimize the extent or impact of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers lessens plasma concentration of abemaciclib and its metabolites.There is no average intravenous dose of Nembutal Sodium Option (pentobarb